Kisspeptin
Kisspeptin (Metastin)
A neuropeptide that acts as the master regulator of the reproductive hormone axis (GnRH/LH/FSH). Research in hypogonadism, fertility, and sexual behavior.
Kisspeptin is not approved by the FDA for human use. It is sold strictly for research purposes only and is not intended for human consumption, diagnosis, treatment, or prevention of any disease or condition. Purchase and use is entirely at your own risk.
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View at Ascension Peptides →What it is
Kisspeptin is a neuropeptide encoded by the KISS1 gene that acts on the kisspeptin receptor (GPR54) in hypothalamic neurons to stimulate GnRH (gonadotropin-releasing hormone) release. This makes it the upstream master regulator of the entire reproductive hormone axis — GnRH → LH/FSH → testosterone/estrogen.
In both men and women, kisspeptin dysfunction has been identified as a cause of hypothalamic hypogonadism. Research has expanded into fertility treatment, sexual behavior, and hormone optimization.
What research shows
- Potent stimulation of LH and FSH release in human studies
- Restoration of LH pulsatility in hypothalamic hypogonadism
- Improved sexual desire and brain activation in response to sexual stimuli in male trials
- Fertility research — triggering ovulation in IVF protocols
- Potential role in male hypogonadism without suppressing endogenous testosterone production (unlike exogenous testosterone)
What remains unknown
- Optimal dosing and pulsing protocols for hormone optimization in healthy individuals
- Long-term safety profile with chronic use
- Clinical utility versus established treatments like clomiphene or TRT for hypogonadism
Administration basics
Common use cases
Hormone axis support, hypogonadism, fertility, libido. Potentially relevant as an alternative to TRT that preserves endogenous production.
Half-life
~28 minutes (Kisspeptin-10). Longer forms exist with extended half-life.
Administration
Subcutaneous injection. Dosing frequency depends on the kisspeptin analogue used.
Source this compound
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View at Ascension PeptidesResearch Protocols & Common Usage
Doses used in research
- Research studies have used 1–10mcg/kg intravenously
- Subcutaneous community protocols commonly report 100–500mcg per injection
Administration routes studied
Typical protocol duration
Research protocols have used both acute doses and multi-week protocols. Community use varies significantly.
Common stacking protocols
- Kisspeptin is typically used standalone for hormone axis support
- Should not be combined with exogenous testosterone or anabolic steroids
Contraindications & combinations to avoid
- Hormone-sensitive cancers (prostate, breast) — Kisspeptin stimulates LH/FSH and downstream sex hormone production
- Exogenous testosterone or anabolic steroids — directly counteracts the intended mechanism
- Active fertility treatments — consult a reproductive endocrinologist before use
Dosing information reflects doses used in published research and commonly reported community protocols only. This is not a personal recommendation. These compounds are not FDA-approved for human use in the contexts described. Consult a qualified healthcare provider before starting any protocol.
Considering stacking?
See the stacking guide for common combinations with Kisspeptin and what to avoid.
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Community Reviews
Reviews reflect individual user experiences with research compounds and are not medical advice. Results vary. These compounds are not FDA approved for human use. Peptelligent does not verify reported experiences.
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